Livre blanc du Tritium & bilan des rejets de tritium pour les INB

254 Les effets biologiques et sanitaires du tritium : questions d’actualité et que l’effet d’une exposition chronique à du tritium organiquement lié serait supérieur d’un facteur 4 à 6 à celui d’une exposition aiguë à de l’eau tritiée. Néanmoins, les données disponibles sont très insuffisantes, et l’évaluation des incertitudes quant à l’estimation des DPUI controversée (CERRIE, 2004). Des organismes tels que le CERI (2003), le CERRIE (2004) ou AGIR (HPA, 2007) nuancent fortement pour leur part les recommandations de laCIPR,etpréconisentlamiseenoeuvred’étudesépidémiologiques,ainsi que le développement de la recherche selon trois axes (effets sanitaires, biocinétique et efficacité biologique relative) pour les différentes formes de tritium. Enfin, dans une perspective de prévention et quelle que soit la perspective adoptée aujourd’hui en radioprotection, il conviendrait de définir, à titre indicatif, des limites dérivées de contamination des aliments et des milieux. Mais une telle démarche supposerait qu’une réponse a été apportée aux interrogations relatives à la biocinétique du tritium chez l’homme et dans l’environnement. RÉFÉRENCES BIBLIOGRAPHIQUES AECB (1989). Childhood Leukemia around Canadian Nuclear Facilities -Phase 1. A Report prepared by the Ontario Cancer Treatment and Research Foundation. Ottawa, Canada. AECB (1991a). Childhood Leukemia around Canadian Nuclear Facilities - Phase II-Final Report. A Report prepared by the Ontario Cancer Treatment and Research Foundation. AECB-INFO-0300-2. Ottawa, Canada. AECB (1991b).TritiumReleases fromthePickeringNuclearGenerating Station and Birth Defects and Infant Mortality in Nearby Communities 1971‑1988, Atomic Energy Control Board, Report INFO‑0401. Ottawa, Canada. Balonov MI, Muskinova KN, Mushkacheva GS (1993). Tritium radiobiological effects in mammals : Review of experiments of the last decade in Russia. Health Phys, 65 : 713-726. Bhatia AL (2005). Radiation risk: technological perspective and public perception of tritium toxicity in the environment. Proceedings of the 9th International Conference on Environmental Science and Technology. Rhodes Island, Greece, 1-3 september 2005. Bogen DC, Welford GA, White CG (1979). Tritium distribution in man and his environment. (IAEA – SM 232/75), AEIA. OCDE, AEN, Behaviour of tritium in the environment, San Francisco, 16-20 octobre 1978, Vienne, AIEA. Carsten AL (1979). Tritium in the environment : isotopic effects and transmutation. In Advances in Radiation Biology, 8, 419-458 (Lett JT, Adler H, eds). New York, Academic Press. Carsten AL, Commerford SL, Cronkite EP (1977). The genetic and late somatic effects of chronic tritium ingestion in mice. Curr Top Radiat Res, 12 : 212-224. CERI (2003).Etudesdeseffetssanitairesdel’expositionauxfaiblesdoses de radiations ionisantes à des fins de radioprotection. Recommandations 2003 du Comité Européen sur le Risque de l’Irradiation. Edition Frison Roche. CERRIE Report. (2004). Report of the Committee Examining Radiation Risks of Internal Emitters. National, Radiological Protection Board, Chilton, 148 p. http://www.cerrie.org. Clemente GF, Belloni P, DiPietro S, Santori G, Santorani GP (1979). Tritium and plutonium content in the Italian diet and transfer to man. In IAEA. Biological Implications of Radionuclides fromNuclear Industries. Vol II : 257-264. De Vol TA, Powell BA (2004). Theoretical organically bound tritium dose estimates. Health Phys, 86 : 183-186 Dobson RL (1979). The toxicity of tritium. Proceedings of the Symposium Behaviour of Tritium in the Environment. San Francisco, 16-20 octobre 1978, Vienne, AIEA, 1979, pp. 203-213. Dobson RL, Kwan TC (1977). The tritium RBE at low level exposure – Variation with dose, dose rate and exposure duration. Curr. Top. Radiat. Res. Quat. 12  : 44-62. Dubrova YE, Plumb M, Brown J, Boulton E, Goodhead D, Jeffreys AJ (2000). Induction of minisatellite mutaions in the mouse germline by low-dose chronic exposure to gamma-radiation and fission neutrons. Mut Res. 453 : 17-24. Duport P, Flüry-Hérard A, Rabin E (1996). Effets biologiques et risques liés au tritium. In Belot Y, Roy M, Métivier H (Dir.) Le tritium, de l’environnement à l’homme. Les Editions de Physique, 1996, 190 p. Feinendegen LE, Bond VP (1971). Transmutaton versus beta irradiation in the pathological effects of tritium decay. In Tritium (Moghissi A.A, Carter M.W., eds). Nevada, Messenger Graphics, 221231. Frankenberg D, Frankenberg-Schwager M, Garg I, Pralle E, Uthe D, Geve B, Severin E, Göhde W (2002). Mutation induction and neoplastic transformation in human and human hamster-hybrid cells: dependance on photon energy and its modulation in the low dose range. J Radiol Prot, A17-A20. Geraschchenko BI, Howell RW (2004). Proliferative response of bystander cells adjacent to cells with incorporated radioactivity. Cytometry, 60A : 155-164. Geraschchenko BI, Howell RW (2005). Bystander cell proliferation is modulated by the number of adjacent cells that were exposed to ionizing radiation. Cytometry, 66A : 62-70. Gragtmans NJ, Myers DK, Johnson JR, Jones AR, Johnson LD (1984) Occurrence of Mammary Tumors in Rats after Exposure to Tritium Bêta Rays and 200-kVp X rays. Rad Res, 99 : 636-650. Hamby DM, Palmer TS (2001). Analysis of an internal kinetic model for free and bound tritium. Health Phys, 81 : 426-437. Hamilton TH, van Belle G, LoGeerfo JP (1987)Thyroid Neoplasia in Marshall Islanders Exposed to Nuclear Fallout. Jama. 258 : 629-636. Health Protection Agency (2007). Review of Risks from Tritium. Report oh the independant Advisory Group on Ionising Radiation. Documents of the Health Protection Agency, Radiation, Chemical and Environment Hazards, November 2007, 90 p. Hisamatsu S, Ohimura T, Takizawa Y, Katsumata T, Inoue Y, Itoh M, Ueno K, Sakanoue M (1992). Tritium level in Jaanese diet and human tissue. J Radioanal Nucl Chem, 156 : 89-102. ICRP (1989). Age-dependant Doses to members of the public from intakes of radionuclides. Publication 56. Part 1. Pergamon Press, Oxford. ICRP (2007a).Draft GuidanceDocument. BioassayData Interpretation. www.icrp.org/news_guidance.asp. Cité par Health Protection Agency (2007). Review of Risks from Tritium. Report oh the independant Advisory Group on Ionising Radiation. Documents of the Health protection Agency. Radiation, Chemical and Environemental Hazards. ICRP (2007b). Recommendations of the International Commission on Radiological Protection. Publication 103. Elsevier Science Ltd. Oxford. Jha AN, Dogra Y, Turner A, Millward GE (2005). Impact of low doses of tritium on the marinje mussel, Mytilus edulis: Genotoxic effects and tissue-specific bioconcentration. Mut. Res., 586 : 47-57. Johnson JR, Myers DK Jackson JS, Dunford DW. Gragtmans NJ, Wyatt HM, Jones AR, Recy DH (1995). Relative Biological Effectiveness of tritium for Induction of Myeloïd Leukemia in CBA/H Mice. Rad Res, 144 : 82-89. Kamiguchi Y, Tateno H. Mikamo K (1990a). Dose-response relationship for the induction of structural chromosome aberration in human spermatozoa aftrt in vitro exposure to tritium ß-rays. Mut Res, 228 : 125-131. Kamiguchi Y, Tateno H, Mikamo K (1990b). Types of structural chromosome aberrations and their incidences in human spermatozoa X-irradiated in vitro. Mut Res, 228 : 133-140. Krasin F, Person S, Ley RD, Hutchinson F (1976). Local effect for (5-3H) cytosine decays. J Mol Biol, 105 : 445 Lambert BE, Clifton RJ (1968). Radiation doses resulting from the ingestion of tritiated thymidine by the rat. Health Phys, 15 : 3-9.

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